Alzheimer hastalığı, hafızayı, düşünmeyi ve davranışı etkileyen ilerleyici bir beyin bozukluğudur. Yaşlı erişkinlerde bunamanın en yaygın nedenidir ve beyindeki nöronların ve sinapsların kaybı ile karakterizedir. Son araştırmalar, ebegümeci bitkisindeki bir bileşiğin Alzheimer’ı yenme potansiyeline sahip olduğunu bulmuştur.
Bir fincan yakut kırmızısı ebegümeci çayının tadını çıkarmak için kışın vücudu ısıtma, bağışıklık sistemini güçlendirme, kan basıncını düzenleme ve kilo vermeye yardımcı olma gibi pek çok neden vardır. Şimdi, araştırma yenebileceğini buldu[{” attribute=””>Alzheimer’s disease.
Professor Kyong-Tai Kim and Ph.D. candidate Kyung Won Jo, from the Department of Life Sciences at the Pohang University of Science & Technology (POSTECH), have found that the gossypetin in hibiscus activates microglia, the immune cells in the brain. Their research also showed that these microglia can scavenge amyloid-beta in the brain to improve cognitive function in individuals with Alzheimer’s disease.
AD begins as Aβ and Tau protein aggregates form deposits in the brain tissue. Microglia internalize such aggregates (phagocytosis) to protect the brain. However, incessant exposure to Aβ will ultimately exhaust the microglia, leading to a chronic inflammatory reaction and damage in the nerve cells. As a result, the victim suffers cognitive decline and memory loss.
While looking for a new AD treatment without serious side effects, the POSTECH team focused on gossypetin, a flavonoid compound found in hibiscus, also known as Hibiscus sabdariffa or roselle.
Gossypetin administration and the subsequent changes in the brain tissue affected by Alzheimer’s disease. Credit: POSTECH
The research team treated AD model mice with gossypetin through intragastric administration for three months and concluded that their impaired memory and cognition were almost restored to the normal level. Furthermore, they saw a decrease in the various types of Aβ aggregates, which are commonly found in the brain tissue with AD-type dementia.
The researchers then collaborated with Professor Jong Kyoung Kim (Department of Life Sciences at POSTECH) and proceeded with single-cell RNA sequencing. The analysis demonstrated that gossypetin prevented the expression of genes associated with gliosis, which promotes chronic inflammatory reactions while increasing the expression of genes associated with Aβ phagocytosis. In other words, gossypetin facilitated microglia’s Aβ clearance.
Professor Kyong-Tai Kim explained, “We have confirmed that removing Aβ aggregates deposited in the brain is effective in preventing and treating dementia. Gossypetin from hibiscus will contribute to the development of a safe and affordable drug for patients suffering from AD.”
Reference: “Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ” by Kyung Won Jo, Dohyun Lee, Dong Gon Cha, Eunji Oh, Yoon Ha Choi, Somi Kim, Eun Seo Park, Jong Kyoung Kim and Kyong-Tai Kim, 21 October 2022, Alzheimer’s Research & Therapy.
DOI: 10.1186/s13195-022-01096-3
The study was conducted with the support from NovMetaPharma Co., and clinical trials are planned for developing a treatment for dementia prevention and treatment that use gossypetin.